If you've watched the latest video (http://www.silkyvenom.com/forums/showthread.php?t=4918
), you'll notice the targeting system at work. Your main enemy target is in the upper right hand of the screen, while your defensive target is below your own stats on the upper left. The smaller stat boxes on the right are all the other mobs your group is currently 'engaged' with. You can only cast/use one spell or ability at a time, but they are 'smart' and are automatically used on the appropriate target.